Diverse Sesquiterpenoids from the Roots of <i>Croton crassifolius</i> and Their Inhibitory Effects on Ferroptosis

Abstract

Abstract One new sesquiterpenoid, 10‐ epi ‐lochmolin F ( 1 ), together with 13 known sesquiterpenoids, was isolated from the roots of Croton crassifolius . The structures of these compounds were confirmed by UV, IR, MS, and NMR spectroscopic analysis. The absolute configuration of compound 1 was elucidated by analysis of X‐ray crystallography. All the 14 isolated sesquiterpenoids were screened for their inhibitory effects on ferroptosis in HT‐22 cells. Two compounds 4 and 7 showed certain inhibitory effects against RSL3‐induced ferroptosis with EC 50 values of 10.8±2.3 μM and 15.5±0.5 μM, respectively. Here we firstly reported the sesquiterpenoids from C. crassifolius showing inhibitory effect on ferroptosis.