Concepedia

Activation of RKIP Binding ASC Attenuates Neuronal Pyroptosis and Brain Injury via Caspase-1/GSDMD Signaling Pathway After Intracerebral Hemorrhage in Mice

Lingui Gu, Mingjiang Sun, Ruihao Li, Yihao Tao, Xu Luo, Jing Xu, Xuan Wu, Zongyi Xie

Translational Stroke Research · 2022 · 44 citations · 34 references

DOI

Concepts

References

34

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu, Zhibin Zhang, Jianbin Ruan et al. · Nature · 2016 · 3.2K citations · Full text

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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

Jun Hu, Xing Liu, Shiyu Xia et al. · Nature Immunology · 2020 · 1.1K citations · Full text

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Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

Kun Wang, Qi Sun, Xiu Zhong et al. · Cell · 2020 · 760 citations · Full text

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Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

Vandana Kaushal, Rebecca Dye, Prateep Pakavathkumar et al. · Cell Death and Differentiation · 2015 · 308 citations

, , +16

NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage

Qingyi Ma, Sheng Chen, Qin Hu et al. · Annals of Neurology · 2013 · 296 citations

, , +17