<i>TERT</i> promoter C228T mutation in neural progenitors confers growth advantage following telomere shortening <i>in vivo</i>

Abstract

Our novel GBM models presented the growth advantage of heterozygous TPMs for the first time in the context of GBM driver mutations relative to isogenic controls, thereby allowing for the identification and validation of TERT promoter-specific vulnerabilities in a genetically accurate background.