Tomoyuki Koga

Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity

Kristen M. Turner, Viraj Deshpande, Doruk Beyter et al. · Nature · 2017 · 854 citations

Somatic Variant, Tumor Heterogeneity, Genetics +4

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

David A. Nathanson, Beatrice Gini, Jack Mottahedeh et al. · Science · 2013 · 665 citations · Full text

NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling

Sudhir Chowdhry, Ciro Zanca, Utkrisht Rajkumar et al. · Nature · 2019 · 217 citations · Full text

Tumor Biology, Gene Amplification, Enhancer Remodelling +14

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

Jianhui Ma, Jorge A. Benítez, Jie Li et al. · Cancer Cell · 2019 · 157 citations · Full text

Radiation Oncology, Genome Instability, Attenuated Dna Repair +8

Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice

Masato Koike, Masahiro Shibata, Yoshiyuki Ohsawa et al. · Molecular and Cellular Neuroscience · 2003 · 150 citations

Inflammation, Ocular Disease, Signal Transduction +10