Gut‐brain axis dysfunction underlies <scp>FODMAP</scp>‐induced symptom generation in irritable bowel syndrome

Abstract

Fructans increase small bowel motility and colon gas and volume similarly in IBS patients and HC. Increased symptom responses to fructans in IBS covary with altered brain responses in pain-related regions, indicating that gut-brain axis dysregulation may drive FODMAP-induced symptom generation in IBS.