Concepedia

Publication | Open Access

Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy

DOIFull Paper Access

18

Citations

55

References

2022

Year

Mario R. Fernandez, Franz X. Schaub, Chunying Yang, Weimin Li, Seongseok Yun, Stephanie K. Schaub, Frank C. Dorsey, Min Liu, Meredith A. Steeves, Andrea Ballabio,
Cancer Research

Abstract

MYC suppresses TFEB and autophagy and controls amino acid homeostasis by upregulating amino acid transport and the proteasome, and reactivation of TFEB disables the metabolism of MYC-driven tumors.

References

YearCitations

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