Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway - Concepedia

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Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway

DOI Full Paper Access

81

Citations

40

References

2022

Year

Yinquan Fang, Xiao Ding, Yihe Zhang, Lei Cai, Yuan Ge, Kaiyang Ma, Rong Xu, Shanshan Li, Mengmeng Song, Hong Zhu,

Journal of Neuroinflammation

Abstract

These data demonstrate that fluoxetine restricts reactive A1 astrocyte via astrocytic 5-HT<sub>2B</sub>R/β-arrestin2 pathway in a mouse model of MDD and provide a novel therapeutic avenue for MDD.

References

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