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Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection

MedicineNatural SciencesImmunologyMolecular BiologyTherapeutic Monoclonal AntibodyAntibody ScreeningImmunochemistryNucleic Acid AmplificationProtein EngineeringAntibody EngineeringAffinity ImprovementImmunotherapyMolecular DiagnosticsDna Aptamer