Molecular Therapy — Nucleic Acids · 2022 · 69 citations · 46 references
Life SciencesCancer BiologyMolecular BiologyEpigeneticsGene ExpressionMolecular OncologyGlioblastomaMetabolic ReprogrammingMetabolic Reprogramming In CancerMicrorna BiogenesisMicrorna BiologyMicrorna-mediated RegulationGlioblastoma MetabolismGlioblastoma Molecular PathwaysGlioblastoma Tumor BiologyMicrorna Function In CancerMicrorna In CancerMicrorna Regulation In CancerPost-transcriptional RegulationPri-microrna Processing
A modification of primary microRNA-10a (pri-miR-10a), which could be recognized by reader HNRNPA2B1, recruiting the microRNA microprocessor complex protein DGCR8 and mediating pri-miR-10a processing. Furthermore, the transcriptional activity of FTO was inhibited by the transcription factor SPI1, which could be specifically disrupted by the SPI1 inhibitor DB2313. Treatment with this inhibitor restored endogenous FTO expression and decreased GBM tumor burden, suggesting that FTO may serve as a novel prognostic indicator and therapeutic molecular target of GBM.
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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Guifang Jia, Ye Fu, Xu Zhao et al. · Nature Chemical Biology · 2011 · 4.1K citations