Molecular Therapy — Methods & Clinical Development · 2022 · 15 citations · 43 references
MedicineOphthalmologyVision ScienceDrug DeliveryGene DeliveryGene TherapyAge-related Macular DegenerationAngiogenesisMacular DegenerationOcular Gene DeliveryOcular Gene TherapyOcular Targeted DeliveryAdeno-associated Viral VectorsAdverse Ocular EffectsAnti-vegf Ocular TherapyMacular NeovascularizationNeovascular Macular DegenerationNeovascularizationVascular Endothelial Growth Factor ReceptorsVegfr Inhibitors
genome copies of AAV8-nVEGFi exhibited a significantly increased reduction in the CNV area compared with AAV8-aflibercept (78.1% vs. 63.9%, p < 0.05), while causing no structural or functional changes to the retina. In conclusion, this preclinical study showed that subretinal injection of AAV8-nVEGFi was long lasting, well tolerated, and effective for nAMD treatment, supporting future translation to the clinic.
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Stephen R. Russell, Jean Bennett, Jennifer Wellman et al. · The Lancet · 2017 · 1.9K citations
VEGF-Trap: A VEGF blocker with potent antitumor effects
Jocelyn Holash, Sam Davis, Susan D. Croll et al. · Proceedings of the National Academy of Sciences · 2002 · 1.7K citations
Medicine, Oncology, Pharmacology +17
In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni
Eunji Kim, Taeyoung Koo, Sung Wook Park et al. · Nature Communications · 2017 · 740 citations · Full text
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