Concepedia

Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation

Shigeki Tashiro, Masatake Tanaka, Takeshi Goya, Tomomi Aoyagi, Miho Kurokawa, Koji Imoto, Akifumi Kuwano, Motoi Takahashi, Hideo Suzuki, Motoyuki Kohjima,

Toxicology and Applied Pharmacology · 2021 · 15 citations · 56 references

DOIFull text

Open access

Concepts

References

56

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

Hideaki Kamata, Shinichi Honda, Shin Maeda et al. · Cell · 2005 · 1.8K citations · Full text

, , +14

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

Mitchell R. McGill, Matthew R. Sharpe, C. David Williams et al. · Journal of Clinical Investigation · 2012 · 763 citations · Full text

, , +17

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

Naoko Hanawa, Mie Shinohara, Behnam Saberi et al. · Journal of Biological Chemistry · 2008 · 527 citations · Full text

, , +17

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

Shinya Tsurusaki, Yuichi Tsuchiya, Tomoko Koumura et al. · Cell Death and Disease · 2019 · 511 citations · Full text

, , +17

Antifibrotic action of pirfenidone and prednisolone: Different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis

Hisashi Oku, Toshikatsu Shimizu, Tomoji Kawabata et al. · European Journal of Pharmacology · 2008 · 438 citations

, , +16