AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

Ken Y. Chan, Min Jee Jang, Bryan B. Yoo et al. · Nature Neuroscience · 2017 · 1.6K citations · Full text

Regenerative Medicine, Tissue Engineering, Cell-based Drug Delivery +12

Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection

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Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

Kevin D. Foust, Emily Nurre, Chrystal L. Montgomery et al. · Nature Biotechnology · 2008 · 1.4K citations · Full text

Intravascular Aav9, Neurophysiology, Medicine +8

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

Benjamin E. Deverman, Piers L. Pravdo, Bryan P. Simpson et al. · Nature Biotechnology · 2016 · 1K citations · Full text

Widespread Gene Transfer, Genetics, Neuroscience +5

Gene therapy clinical trials worldwide to 2017: An update

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