Concepedia

Discovery of new chiral sulfonamides bearing benzoxadiazole as HIF inhibitors for non-small cell lung cancer therapy: design, microwave-assisted synthesis, binding affinity,<i>in vitro</i>antitumoral activities and<i>in silico</i>studies

Demet Taşdemir Kahraman, Ayşegül Karaküçük‐İyidoğan, Yasemin Saygıdeğer, Emine Elçin Oruç‐Emre, Tuğba Taşkın‐Tok, Eyüp Başaran, Sedat İlhan, Burcu Saygıdeğer Demir, Aykut Üren, Hasan Bayram

New Journal of Chemistry · 2021 · 12 citations · 33 references

DOI

Concepts

Abstract

Thirty-four chiral compounds having benzoxadiazole and sulfonamide moieties on the skeleton have been synthesized. The in vitro cytotoxic activity and apoptotic effects of these compounds have been evaluated using the A549 lung cancer cell line.

References

33

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Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

Cheng‐Jun Hu, Li-Yi Wang, Lewis A. Chodosh et al. · Molecular and Cellular Biology · 2003 · 1.4K citations · Full text

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Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

Gregg L. Semenza · Physiology · 2009 · 926 citations

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