Concepedia

BRAF<sup>V600E</sup> mutant colorectal cancer cells mediate local immunosuppressive microenvironment through exosomal long noncoding RNAs

Zhi Jie, Xiaojing Jia, Jing Yan, Huicong Wang, Bo Feng, Hanying Xing, Yitao Jia

World Journal of Gastrointestinal Oncology · 2021 · 37 citations · 29 references

DOIFull text

Open access

Abstract

BRAF<sup>V600E</sup> mutant CRC cells can reach the tumor microenvironment by releasing exosomal lncRNAs, and induce the formation of an immunosuppressive microenvironment.

References

29

Cancer statistics, 2019

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2019 · 20.7K citations · Full text

, , +19

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.6K citations · Full text

, , +5

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

Tian Fang, Hongwei Lv, Guishuai Lv et al. · Nature Communications · 2018 · 1K citations · Full text

ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation

Olga Tornavaca, Minghao Chia, Neil Dufton et al. · The Journal of Cell Biology · 2015 · 556 citations · Full text

Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

Yuan Zhou, Haozhen Ren, Bo Dai et al. · Journal of Experimental & Clinical Cancer Research · 2018 · 433 citations · Full text