Concepedia

Increased glycolysis affects β-cell function and identity in aging and diabetes

Naoya Murao, Norihide Yokoi, Harumi Takahashi, Tomohide Hayami, Yasuhiro Minami, Susumu Seino

Molecular Metabolism · 2021 · 53 citations · 75 references

DOIFull text

Open access

Abstract

Our study demonstrates that hyperactive glycolysis is a metabolic signature of aged and diabetic β cells, which may underlie age-related β-cell dysfunction and loss of cellular identity. We suggest Nmnat2 suppression as an approach to counteract age-related T2D.

References

75

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

N.H. Cho, Jonathan E. Shaw, Suvi Karuranga et al. · Diabetes Research and Clinical Practice · 2018 · 7.2K citations

, , +8

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Haiyan Xu, Glenn T. Barnes, Qing Yang et al. · Journal of Clinical Investigation · 2003 · 5.8K citations · Full text

, , +18

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Haiyan Xu, Glenn T. Barnes, Qing Yang et al. · Journal of Clinical Investigation · 2003 · 5.6K citations

, , +18

Heatmapper: web-enabled heat mapping for all

Sasha Babicki, David Arndt, Ana Marcu et al. · Nucleic Acids Research · 2016 · 2.4K citations · Full text

, , +20

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

Chutima Talchai, Shouhong Xuan, Hua Lin et al. · Cell · 2012 · 1.4K citations · Full text

, , +4