Concepedia

Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ

Jing Cai, Mei Yi, Yixin Tan, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong, Bo Xiang

Journal of Experimental & Clinical Cancer Research · 2021 · 195 citations · 44 references

Open access

Abstract

This study not only provides a new paradigm of TPL in cancer therapy, but also highlights a crucial role of mitochondrial HK-II in linking glucose metabolism with pyroptosis.

References

44

On the Origin of Cancer Cells

Otto Warbürg · Science · 1956 · 13.1K citations

Human Cell, Months1,079total Citations9,249last 6, Engineering +13

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.2K citations

Inflammation, Signal Transduction, Signaling Pathway +12

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang, Wenqing Gao, Xuyan Shi et al. · Nature · 2017 · 3K citations

Medicine, Apoptosis, Pyroptosis +9

Pore-forming activity and structural autoinhibition of the gasdermin family

Jingjin Ding, Kun Wang, Wang Liu et al. · Nature · 2016 · 2.6K citations

Gasdermin Family, Protein Secretion, Biochemistry +2

Differential expression in RNA-seq: A matter of depth

Sonia Tarazona, Fernando García-Alcalde, Joaquı́n Dopazo et al. · Genome Research · 2011 · 1.7K citations · Full text