Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Serena Nik‐Zainal, Helen Davies, Johan Staaf, +84

Nature

Somatic VariantSomatic MutationsTumor HeterogeneityMedicineGenetics +6

A constant rate of spontaneous mutation in DNA-based microbes.

John W. Drake

Proceedings of the National Academy of Sciences

Base PairMolecular EcologyComparative GenomicsGeneticsEvolutionary Biology +13

Yeast DNA Polymerase ε Participates in Leading-Strand DNA Replication

Zachary F. Pursell, Isabelle Isoz, Else-Britt Lundström, +2

Science

Division of Labor at the Eukaryotic Replication Fork

Stephanie A. Nick McElhinny, Dmitry A. Gordenin, Carrie M. Stith, +2

Molecular Cell

BiologyUnicellular OrganismCell DivisionNatural SciencesGenetics +6

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication

Joseph T.P. Yeeles, Agnieska Janska, Anne Early, +1

Molecular Cell

Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity.

Alan Morrison, Juliette B. Bell, Thomas A. Kunkel, +1

Proceedings of the National Academy of Sciences

Nucleic Acid ChemistryCellular EnzymologyBiochemistryExonuclease ActivityNatural Sciences +13

Pathway correcting DNA replication errors in Saccharomyces cerevisiae.

Alan Morrison, Andrew L. Johnson, Leland H. Johnston, +1

The EMBO Journal

Genome InstabilityNatural SciencesGeneticsMolecular BiologyDna Replication +4

Lagging-strand replication shapes the mutational landscape of the genome

Martin A.M. Reijns, Harriet Kemp, James Ding, +3

Nature

Genome InstabilityGeneticsGenomic MechanismDna ReplicationGene Evolution +2

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ

M.K. Swan, Robert E. Johnson, Louise Prakash, +2

Nature Structural & Molecular Biology

BiochemistryNatural SciencesOligonucleotideDna ReplicationMolecular Biology +4

DNA polymerase ε and δ proofreading suppress discrete mutator and cancer phenotypes in mice

Tina Albertson, Masanori Ogawa, James M. Bugni, +7

Proceedings of the National Academy of Sciences

Dna Polymerase εCancer PhenotypesGeneticsFaithful Dna ReplicationTumor Biology +14