Transcriptional Co-Activators YAP1–TAZ of Hippo Signalling in Doxorubicin-Induced Cardiomyopathy

Abstract

Our results suggest that Hippo signalling is involved in clinical anthracycline-induced cardiomyopathy. Modelling with hiPSC-CMs in vitro showed similar responses to doxorubicin as adult cardiomyocytes and revealed a potential cardioprotective effect of YAP in doxorubicin-induced cardiotoxicity.