The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice

Abstract

Estrogen decline in menopause may cause neuroinflammation by reducing intracellular Mg²⁺ in neurons, leading to chronic pain, memory/emotional deficits. Supplement Mg²⁺ by oral magnesium-L-threonate may be a novel approach for treating menopause-related neuronal disorders.