Concepedia

Computational Prediction of Biomarkers, Pathways, and New Target Drugs in the Pathogenesis of Immune-Based Diseases Regarding Kidney Transplantation Rejection

Rafael Alfaro, Helios Martínez‐Banaclocha, Santiago Llorente, Víctor Jiménez-Coll, José Galián, Carmen Botella, María Rosa Moya‐Quiles, Antonio Parrado, Manuel Muro-Pérez, Alfredo Minguela,

Frontiers in Immunology · 2021 · 17 citations · 70 references

DOIFull text

Open access

Abstract

Our results suggest the importance of the IRF/STAT1 pathways in humoral kidney rejection. NK cells and monocytes in graft damage have an essential role during rejection, and imatinib improves KT outcomes. Our results will have to be validated for the potential use of overexpressed genes as rejection biomarkers that can be used as diagnostic and prognostic markers and as therapeutic targets to avoid graft rejection in patients undergoing kidney transplantation.

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