Concepedia

Involvement of autophagy in the maintenance of rat intervertebral disc homeostasis: an in-vitro and in-vivo RNA interference study of Atg5

Ryu Tsujimoto, Takashi Yurube, Yoshiki Takeoka, Yutaro Kanda, Kunihiko Miyazaki, Hiroki Ohnishi, Yuji Kakiuchi, Shuya Miyazaki, Z. Zhang, Tomoaki Takada,

Osteoarthritis and Cartilage · 2021 · 21 citations · 36 references

DOIFull text

Open access

Abstract

This loss-of-function study suggests Atg5-dependent autophagy-mediated anti-apoptosis and anti-senescence. Autophagy could be a molecular therapeutic target for degenerative disc disease.

References

36

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, , +16

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

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Autophagy in the Pathogenesis of Disease

Beth Levine, Guido Kroemer · Cell · 2008 · 6.9K citations · Full text

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Yukihiro Kabeya · The EMBO Journal · 2000 · 6.5K citations · Full text

, , +9

Expenditures and Health Status Among Adults With Back and Neck Problems

Brook I. Martin · JAMA · 2008 · 1.5K citations