Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration

Takashi Yurube, Toru Takada, Teppei Suzuki, +5

Arthritis Research & Therapy

Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction

Masaaki Ito, Takashi Yurube, Kenichiro Kakutani, +8

Osteoarthritis and Cartilage

Cell AutophagyMtorc1/raptor ProtectsCell RegulationAutophagy InductionApoptosis +8

Development of a standardized histopathology scoring system for intervertebral disc degeneration in rat models: An initiative of the <scp>ORS</scp> spine section

Alon Lai, Jennifer Gansau, Sarah E. Gullbrand, +16

JOR Spine

Notochordal cell disappearance and modes of apoptotic cell death in a rat tail static compression-induced disc degeneration model

Takashi Yurube, Hiroaki Hirata, Kenichiro Kakutani, +8

Arthritis Research & Therapy

Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells

Shingo Miyazaki, Kenichiro Kakutani, Takashi Yurube, +11

Arthritis Research & Therapy

Intervertebral disc and macrophage interaction induces mechanical hyperalgesia and cytokine production in a herniated disc model in rats

Toru Takada, Kotaro Nishida, Koichiro Maeno, +4

Arthritis & Rheumatism

Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction

Yuji Kakiuchi, Takashi Yurube, Kenichiro Kakutani, +7

Osteoarthritis and Cartilage

A rat tail temporary static compression model reproduces different stages of intervertebral disc degeneration with decreased notochordal cell phenotype

Hiroaki Hirata, Takashi Yurube, Kenichiro Kakutani, +8

Journal of Orthopaedic Research®

C1 laminectomy for retro-odontoid pseudotumor without atlantoaxial subluxation: review of seven consecutive cases

Kenichiro Kakutani, Minoru Doita, Masaho Yoshikawa, +6

European Spine Journal

Retro-odontoid PseudotumorC1 LaminectomyMedicineSpinal TumorSurgery +4

Fas ligand plays an important role for the production of pro‐inflammatory cytokines in intervertebral disc nucleus pulposus cells

Junya Yamamoto, Koichiro Maeno, Toru Takada, +10

Journal of Orthopaedic Research®