Imaging Features with Histopathologic Correlation of CNS High-Grade Neuroepithelial Tumors with a <i>BCOR</i> Internal Tandem Duplication

Abstract

CNS tumors with a <i>BCL6</i> corepressor gene internal tandem duplication present as large intra-axial peripheral masses with well-defined borders, no edema, restricted diffusion, weak contrast enhancement, frequent central necrosis, hemorrhage and calcifications, intratumoral veins, and no leptomeningeal dissemination at the time of diagnosis. Knowledge of these imaging characteristics may aid in histologic, genomic, and molecular profiling of brain tumors in young children.