Concepedia

pH-Metric Solubility. 2: Correlation Between the Acid-Base Titration and the Saturation Shake-Flask Solubility-pH Methods

Alex Avdeef, Cynthia M. Berger, Charles Brownell

Pharmaceutical Research · 2000 · 257 citations · 9 references

DOI

Concepts

References

9

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

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A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah et al. · Pharmaceutical Research · 1995 · 5.3K citations · Full text

, , +16

Microelectrometric titration measurement of the pKa's and partition and drug distribution coefficients of narcotics and narcotic antagonists and their pH and temperature dependence

Joyce J. Kaufman, Nora Semo, W. S. Koski · Journal of Medicinal Chemistry · 1975 · 212 citations

, , +8

Predictive Relationships in the Water Solubility of Salts of a Nonsteroidal Anti-Inflammatory Drug

Bradley D. Anderson, Robert A. Conradi · Journal of Pharmaceutical Sciences · 1985 · 151 citations

, , +16

Aqueous solubility and n-octanol/water partition coefficient correlations

P. Isnard, S. M. Lambert · Chemosphere · 1989 · 144 citations

, , +8