PLoS ONE · 2015 · 21 citations · 28 references
IL-17 seemed to have no association with the formation of cavities in active PTB from the study of PBMC. Impaired IFN-γ without IL-17 enhancement occurs in peripheral blood during severe cavitary PTB. Our results demonstrate that M. tuberculosis antigen-specific Th1 response is decreased when PTB lesions develop to severe cavities.
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Generation of pathogenic TH17 cells in the absence of TGF-β signalling
Kamran Ghoreschi, Arian Laurence, Xiang‐Ping Yang et al. · Nature · 2010 · 1.4K citations