Mutation of glutamic acid residue 1046 abolishes Jak2 tyrosine kinase activity

Protein Structure Prediction and Structural Genomics

David Baker, Andrej Šali · Science · 2001 · 1.6K citations

Life Sciences, Bioinformatics, Biology +15

Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

Evan Parganas, Demin Wang, Dimitrios J. Stravopodis et al. · Cell · 1998 · 1.2K citations · Full text

Life Sciences, Immunology, Molecular Biology +11

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

Naftaly Meydan, T Grunberger, Harjit Dadi et al. · Nature · 1996 · 912 citations

Medicine, Hematology, Pharmacology +9

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

William S. Chen, Cheri S. Lazar, Martin Poenie et al. · Nature · 1987 · 600 citations

Life Sciences, Cell Biology, Molecular Biology +14

Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid Leukemia

Pieter J. Peeters, Sophie Raynaud, Jan Cools et al. · Blood · 1997 · 484 citations · Full text

Life Sciences, Genetics, Molecular Biology +11