Concepedia

Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes

Naser Jafari, Manohar Kolla, Tova Meshulam, Jordan Shafran, Yuhan Qiu, Allison N. Casey, Isabella R. Pompa, Christina Ennis, Carla Mazzeo, Nabil Rabhi,

Science Signaling · 2021 · 99 citations · 26 references

DOIFull text

Open access

Concepts

Abstract

correlated with poorer prognosis, specifically decreased distant metastasis–free survival. Our findings reveal a mechanism of exosome-mediated cross-talk between metabolically abnormal adipocytes and breast cancer cells that may promote tumor aggressiveness in patients with T2D.

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