Discovery of an Antarctic Ascidian-Associated Uncultivated <i>Verrucomicrobia</i> with Antimelanoma Palmerolide Biosynthetic Potential

Abstract

. Synoicihabitans palmerolidicus 4.29-Mb genome encodes a repertoire of carbohydrate-utilizing and transport pathways, a chemotaxis system, flagellar biosynthetic capacity, and other regulatory elements enabling its ascidian-associated lifestyle. The palmerolide producer's genome also contains five distinct copies of the large palmerolide biosynthetic gene cluster that may provide structural complexity of palmerolide variants.