Concepedia

ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites

Alejandra Martínez-Chávez, Nancy H.C. Loos, Maria C. Lebre, Matthijs M. Tibben, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel

Pharmacological Research · 2021 · 20 citations · 23 references

DOI

Concepts

References

23

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

Hyuna Sung, Jacques Ferlay, Rebecca L. Siegel et al. · CA A Cancer Journal for Clinicians · 2021 · 112.5K citations · Full text

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PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel

Yong Zhang, Meirong Huo, Jianping Zhou et al. · Computer Methods and Programs in Biomedicine · 2010 · 2.1K citations

, , +7

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

Alfred H. Schinkel, Johan W. Jonker · Advanced Drug Delivery Reviews · 2012 · 1.2K citations

, , +14

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

Alfred H. Schinkel, Ulrich Mayer, Els Wagenaar et al. · Proceedings of the National Academy of Sciences · 1997 · 941 citations

, , +11

Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non–Small Cell Lung Cancer, and Other Solid Tumors

Amita Patnaik, Lee S. Rosen, Sara M. Tolaney et al. · Cancer Discovery · 2016 · 760 citations · Full text

, , +17