Cell Reports · 2021 · 75 citations · 47 references
Life SciencesCancer BiologyImmunologyCancer ImmunologyCellular ImmunologyTumor ImmunologyAntitumor T Cell ResponsesCancer ImmunotherapyCytotoxic T Lymphocyte ResponsesEffector T Cell FunctionT Cell BiologyTumor-infiltrating LymphocytesInhibitory Killer Cell Immunoglobulin-like ReceptorsNatural Killer Cell Inhibitory SignalingT Cell Effector FunctionsT Cell-mediated Tumor ControlT Cell-mediated Tumor KillingT-cell Recruitment
tumors. This is highly relevant in the clinic, as the different degrees of engagement of the NKG2A-HLA-E checkpoint in hepatocellular carcinoma, glioblastoma, and non-small cell lung cancer directly impact patients' overall survival. These findings open avenues for developing combined cellular and immunologic anticancer therapies.
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