Glucocorticoids inhibit human hematopoietic stem cell differentiation toward a common ILC precursor

Abstract

GCs impair the development of the CD117⁺ ILCP from CD34⁺ HSCs, while they do not affect the further steps of ILCP differentiation toward NK cells and hILC subsets. This reflects an association of GC treatment with a marked reduction of circulating hILCs in the recipients of HSC transplantation.