Concepedia

Topical Delivery of Rapamycin by Means of Microenvironment-Sensitive Core-Multi-Shell Nanocarriers: Assessment of Anti-Inflammatory Activity in an ex vivo Skin/T Cell Co-Culture Model

Fiorenza Rancan, Xiao Guo, Keerthana Rajes, Polytimi Sidiropoulou, Fatemeh Zabihi, Luísa Hoffmann, Sabrina Hadam, Ulrike Blume‐Peytavi, E. Rühl, Rainer Haag,

International Journal of Nanomedicine · 2021 · 11 citations · 50 references

DOIFull text

Open access

Abstract

Overall, our results demonstrate that nanocarriers addressing features of diseased skin are promising approaches to improve the topical delivery of macrolide drugs.

References

50

Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.

Rachel Grossman, James G. Krueger, D Yourish et al. · Proceedings of the National Academy of Sciences · 1989 · 848 citations · Full text

, , +13

Enzymic and Non-Enzymic Antioxidants in Epidermis and Dermis of Human Skin

Yasuko Shindo, E Witt, Derick Han et al. · Journal of Investigative Dermatology · 1994 · 532 citations

, , +7

Supramolecular Aggregates of Dendritic Multishell Architectures as Universal Nanocarriers

Michał R. Radowski, Anuj Shukla, Hans von Berlepsch et al. · Angewandte Chemie International Edition · 2007 · 230 citations

, , +11

Serine Protease Signaling of Epidermal Permeability Barrier Homeostasis

Jean‐Pierre Hachem, Evi Houben, Debra Crumrine et al. · Journal of Investigative Dermatology · 2006 · 208 citations · Full text

, , +5

Reactive Oxygen Species in Tumor Necrosis Factor-α-Activated Primary Human Keratinocytes: Implications for Psoriasis and Inflammatory Skin Disease

Chen N. Young, Jay I. Koepke, Laura J. Terlecky et al. · Journal of Investigative Dermatology · 2008 · 196 citations · Full text

, , +10