Kidney & Blood Pressure Research · 2021 · 14 citations · 20 references
Six metabolic pathways were found to be involved in cardiorenal metabolic communication in an adriamycin-induced nephropathy model, in which alanine, aspartate, and glutamate metabolism may be the metabolic link between the heart and kidney in the development and maintenance of oxidative stress and inflammation. Succinic acid may serve as a key regulatory metabolic switch or marker of cardiac and renal co-injury, as shown in an adriamycin-induced nephropathy model.
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Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik et al. · Nature · 2013 · 3.8K citations · Full text
Rajtilak Majumdar, Boubker Barchi, Swathi A. Turlapati et al. · Frontiers in Plant Science · 2016 · 261 citations · Full text