Concepedia

Zn<sup>2+</sup>-Dependent peptide nucleic acid-based artificial ribonucleases with unprecedented efficiency and specificity

Olivia Luige, Partha Pratim Bose, Rouven Stulz, Peter Steunenberg, Omar Brun, Shalini Andersson, Merita Murtola, Roger Strömberg

Chemical Communications · 2021 · 10 citations · 25 references

DOIFull text

Open access

Concepts

Abstract

-dependent dimethyl-dipyridophenazine PNA conjugates as efficient RNA cleaving artificial enzymes. These PNAzymes display site-specific RNA cleavage with 10 minute half-lives and cleave clinically relevant RNA models.

References

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