Nucleic Acids Research · 2021 · 84 citations · 26 references
MedicineBioinformaticsPharmacologyDrug DiscoveryMolecular PharmacologyStructural BioinformaticsDrug DatabasesDrug Discovery InformaticsG Protein-coupled Receptor SignalingProtein Database SearchReceptor ModelingReceptor PharmacologyDrug Binding DatabasesDrug-target Interaction DatabasesG Protein-coupled Receptor BindingG Protein-coupled Receptor Structure-function RelationshipsHeterotrimeric G Protein SignalingHuman PhysiologyProtein Sequence Database ConstructionReceptor-g Protein Coupling
Two-thirds of signaling substances, several sensory stimuli and over one-third of drugs act via receptors coupling to G proteins. Here, we present an online platform for G protein research with reference data and tools for analysis, visualization and design of scientific studies across disciplines and areas. This platform may help translate new pharmacological, structural and genomic data into insights on G protein signaling vital for human physiology and medicine. The G protein database is accessible at https://gproteindb.org.
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SciPy 1.0: fundamental algorithms for scientific computing in Python
Nature Methods · 2020 · 37.9K citations · Full text
Crystal structure of the β2 adrenergic receptor–Gs protein complex
Søren G. F. Rasmussen, Brian T. DeVree, Yaozhong Zou et al. · Nature · 2011 · 3.1K citations · Full text
Comparative Protein Structure Modeling Using MODELLER
Narayanan Eswar, Ben Webb, Marc A. Martı́-Renom et al. · Current Protocols in Protein Science · 2007 · 2.9K citations