USP7 inhibition induces apoptosis in glioblastoma by enhancing ubiquitination of ARF4

Abstract

Targeted inhibition of USP7 enhances the ubiquitination of ARF4 and ultimately mediates the apoptosis of GBM cells. In a clinical sense, P5091 as a novel specific inhibitor of USP7 may be an effective approach for the treatment of GBM.