Zileuton inhibits arachidonate-5-lipoxygenase to exert antitumor effects in preclinical cervical cancer models

Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia

Yaoyu Chen, Yiguo Hu, Haojian Zhang et al. · Nature Genetics · 2009 · 289 citations · Full text

Medicine, Genetics, Molecular Genetics +12

Overexpression of 5-Lipoxygenase in Colon Polyps and Cancer and the Effect of 5-LOX Inhibitors <i>In vitro</i> and in a Murine Model

Laleh G. Melstrom, David J. Bentrem, Mohammad R. Salabat et al. · Clinical Cancer Research · 2008 · 138 citations

Medicine, Oncology, Pharmacology +12

Overexpression of 5-Lipoxygenase and Cyclooxygenase 2 in Hamster and Human Oral Cancer and Chemopreventive Effects of Zileuton and Celecoxib

Ning Li, Sandeep Sood, Su Wang et al. · Clinical Cancer Research · 2005 · 123 citations · Full text

Medicine, Oncology, Pharmacology +12

Overexpression of 5-Lipoxygenase in Rat and Human Esophageal Adenocarcinoma and Inhibitory Effects of Zileuton and Celecoxib on Carcinogenesis

Xiaoxin Chen, Su Wang, Nan Wu et al. · Clinical Cancer Research · 2004 · 102 citations

Medicine, Oncology, Pharmacology +15

Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration

Zhihua Wen, H Liu, Mansheng Li et al. · Oncogene · 2014 · 95 citations

Medicine, Cancer Biology, Oncology +14