Concepedia

α-naphthoflavone-derived cytochrome P450 (CYP)1B1 degraders specific for sensitizing CYP1B1-mediated drug resistance to prostate cancer DU145: Structure activity relationship

Peng Chen, Shaobing Wang, Chenyang Cao, Wenchong Ye, Meizhu Wang, Cui Zhou, Wen-Ming Chen, Xu Zhang, Keyu Zhang, Wen Zhou

Bioorganic Chemistry · 2021 · 17 citations · 22 references

DOI

Concepts

References

22

Catalytic in vivo protein knockdown by small-molecule PROTACs

Daniel P. Bondeson, Alina Mares, Ian E. Smith et al. · Nature Chemical Biology · 2015 · 1.3K citations · Full text

, , +9

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

Tsutomu Shimada, Carrie L. Hayes, Hiroshi Yamazaki et al. · PubMed · 1996 · 795 citations

, , +17

Human CYP1B1 and Anticancer Agent Metabolism: Mechanism for Tumor-Specific Drug Inactivation?

Bertrand Rochat, Janine M. Morsman, G I Murray et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 201 citations

, , +17

Mechanistic Basis for Regioselection and Regiodivergence in Nickel-Catalyzed Reductive Couplings

Evan P. Jackson, Hasnain A. Malik, Grant J. Sormunen et al. · Accounts of Chemical Research · 2015 · 191 citations

, , +14

Cytochrome P450 CYP1B1 protein expression:

Morag McFadyen, Howard L. McLeod, Fiona C Jackson et al. · Biochemical Pharmacology · 2001 · 190 citations

, , +6