Concepedia

Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines

Olga Cruz‐López, Matilde Ner, Francho Nerín-Fonz, Yaiza Jiménez-Martínez, David Alencar Araripe, Juan Antonio Marchal, Houría Boulaiz, Hugo Gutiérrez‐de‐Terán, Joaquín M. Campos Rosa, Ana Conejo‐García

Journal of Enzyme Inhibition and Medicinal Chemistry · 2021 · 14 citations · 25 references

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Concepts

Abstract

0.42-0.86 µM) does not produce any modification in the expression of pro-caspase 3, but increases the caspase 1 expression, and promotes pyroptosis.

References

25

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram et al. · CA A Cancer Journal for Clinicians · 2018 · 87.7K citations · Full text

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Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

Jean-Paul Ryckaert, Giovanni Ciccotti, Herman J. C. Berendsen · Journal of Computational Physics · 1977 · 21.5K citations

, , +11

Glide:  A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database Screening

Thomas A. Halgren, Robert B. Murphy, Richard A. Friesner et al. · Journal of Medicinal Chemistry · 2004 · 5.2K citations

, , +17

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang, Wenqing Gao, Xuyan Shi et al. · Nature · 2017 · 3.2K citations

, , +13

Efficient estimation of free energy differences from Monte Carlo data

Journal of Computational Physics · 1976 · 2.8K citations

, , +14