Stem Cell Reports · 2021 · 21 citations · 5 references
Life SciencesGeneticsMolecular BiologyBioethicsEpigeneticsGenome EditingEpigenetic AlterationsEpigenetic ReprogrammingEpigenome EditingGenetic EthicsTherapeutic Genome EditingClinical Translation Of Genome EditingDna Methylation EditingEpigenome ReprogrammingGene Editing TherapyGenome Editing EthicsSomatic Cell EditingSomatic Gene Editing EthicsTherapeutic Epigenome Editing
Altering the human epigenome with gene-editing technology in attempt to treat a variety of diseases and conditions seems scientifically feasible. We explore some of the ethical and regulatory issues related to the clinical translation of human epigenetic editing arguing that such approaches should be considered akin to somatic therapies. Altering the human epigenome with gene-editing technology in attempt to treat a variety of diseases and conditions seems scientifically feasible. We explore some of the ethical and regulatory issues related to the clinical translation of human epigenetic editing arguing that such approaches should be considered akin to somatic therapies.
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Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene
X. Shawn Liu, Hao Wu, Marine Krzisch et al. · Cell · 2018 · 513 citations · Full text