Implication of Heterozygous Variants in Genes of the Leptin–Melanocortin Pathway in Severe Obesity

Abstract

Heterozygous variants in LEP, LEPR, POMC, and PCSK1 are frequent in severe obesity and sometimes associated with a phenotype close to that of homozygotes. These data suggest a systematic search for variants in severe early-onset obesity, to discuss therapy that targets this key pathway.