NLRP3-inflammasome activation is associated with epithelial-mesenchymal transition and progression of colorectal cancer.

Abstract

This study for the first time showed that activation of NLRP3 inflammasome contributed to the progression of CRC and is correlated with the EMT process. Although the present study showed that EMT markers are positively correlated with tumor grade, further investigations are required to strongly link the EMT markers to the progression of CRC.