Uncovering the signalling, structure and function of the 20‐HETE‐GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75 - Concepedia

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Uncovering the signalling, structure and function of the 20‐HETE‐GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75

DOI Full Paper Access

49

Citations

35

References

2021

Year

Jonathan V. Pascale, Eon Joo Park, Adeniyi Michael Adebesin, John R. Falck, Michal L. Schwartzman, Víctor García

British Journal of Pharmacology

Abstract

We have identified 20-HETE as a high-affinity ligand for GPR75 and CCL5 as a low-affinity negative regulator of GPR75, providing additional evidence for the deorphanization of GPR75 as a 20-HETE receptor.

References

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