Design of a self-sufficient hydride-shuttling cascade for concurrent bioproduction of 7,12-dioxolithocholate and<scp>l</scp>-<i>tert</i>-leucine

Abstract

A highly atom-economic self-sufficient hydride-shuttling cascade was designed to concurrently obtain 7,12-dioxo-lithocholic acid and<sc>l</sc>-<italic>tert</italic>-leucine using only inorganic ammonium as the sacrificial agent and generating water as the by-product.