Characteristics of Ang-(1–7)/Mas-Mediated Amelioration of Joint Inflammation and Cardiac Complications in Mice With Collagen-Induced Arthritis

Abstract

Ang-(1-7) alleviated joint damage caused by inflammation likely through the attenuation of NF-<i>κ</i>B and MAPK pathways and ameliorated inflammation-induced cardiac fibrosis and activation of the TGF-<i>β</i>/Smad pathway. Moreover, Ang-(1-7) was likely mediated through the Mas receptor. This study provides theoretical evidence for exploring novel clinical therapeutic approaches for RA and its cardiac complications.