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Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification

Medicinal ChemistryCovalent InhibitorProtein FunctionProtein AssemblyNatural SciencesMedicineMolecular BiologyChaperonesBiomolecular InteractionCo-chaperone BindingAnti-cancer AgentPharmacologyC-terminal ModificationDrug Discovery