Concepedia

Protective effect and mechanisms of action of Mongolian medicine Sulongga-4 on pyloric ligation-induced gastroduodenal ulcer in rats

Shan Tong, Huan Wang, A Li-Sha, Ta-Na Bai, Juhua Gong, Wenjie Jin, Lili Dai, Gen-Na Ba, Sungbo Cho, Minghai Fu

World Journal of Gastroenterology · 2021 · 12 citations · 19 references

DOIFull text

Open access

Abstract

SL-4 exerts protective effects against PL-induced gastroduodenal ulcers <i>via</i> reducing inflammatory cytokines and elevating expression of gastric acid inhibitory factors. Downregulation of <i>CYP2b2</i> and <i>UGT2b1</i> genes in retinol metabolism and upregulation of <i>A2m</i> and <i>MASP1</i> genes in the complement and coagulation cascades pathways are possibly involved in SL-4-mediated protection against gastroduodenal ulcer.

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