iScience · 2021 · 40 citations · 82 references
Life SciencesCancer BiologyMolecular BiologyCancer GeneticsChromatin BiologyMolecular OncologyCancer EpigeneticsCancer EpigenomicsChromatinChromatin InteractionsEpigenetic Regulation In CancerPolycomb RegulationChromatin RemodelingDruggable Target DiscoveryPolycomb Group RegulationPolycomb RepressionPolycomb Repressive Complex 1Polycomb-mediated Chromatin RepressionPolycomb-mediated Gene RepressionPolycomb-mediated Repression
in human leukemia xenografts. We propose a model where USP7 counteracts TRIM27 E3 ligase activity, thereby maintaining PRC1.1 integrity and function. Moreover, USP7 inhibition may be a promising new strategy to treat AML patients.
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