Developmental & Comparative Immunology · 2021 · 38 citations · 40 references
Life SciencesImmunologyMolecular BiologyInflammationInnate ImmunitySignal TransductionCaspase ActivationCytokine BiologyInflammasome ActivationInflammatory Cell ResponsesInflammatory Cell SignalingInflammatory SignalingCaspase CleavageCaspase SignalingCaspase-mediated Inflammatory SignalingInflammasome RegulationInflammasome ResponsesInflammasome SignalingNoncanonical Inflammasome Activation
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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.5K citations
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
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Non-canonical inflammasome activation targets caspase-11
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