Concepedia

<i>C9orf72</i> -derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

Laura Fumagalli, Florence L. Young, Steven Boeynaems, Mathias De Decker, Arpan R. Mehta, Ann Swijsen, Raheem Fazal, Wenting Guo, Matthieu Moisse, Jimmy Beckers,

Science Advances · 2021 · 90 citations · 51 references

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Abstract

Arginine-rich dipeptide repeats associated with ALS and FTD inhibit machinery for microtubule-based axonal cargo transport.

References

51

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

Jürgen Cox, Marco Y. Hein, Christian A. Luber et al. · Molecular & Cellular Proteomics · 2014 · 5.5K citations · Full text

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A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

Alan E. Renton, Elisa Majounie, Adrian J. Waite et al. · Neuron · 2011 · 4.5K citations · Full text

, , +14

Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in <i>Drosophila</i>

Fillip Port, Hui-Min Chen, Tzumin Lee et al. · Proceedings of the National Academy of Sciences · 2014 · 1.2K citations · Full text

, , +15

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

Ram Dixit, Jennifer L. Ross, Yale E. Goldman et al. · Science · 2008 · 1K citations · Full text

, , +17

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

Ke Zhang, Christopher J. Donnelly, Aaron R. Haeusler et al. · Nature · 2015 · 1K citations

, , +5